Ccn1位于小鼠的3号染色体,采用CRISPR/Cas技术,设计sgRNA和ssDNA,通过高通量电转受精卵方式,获得Ccn1基因条件性敲除小鼠,性成熟后取精子冻存。
相关疾病:
Wilms Tumor 5
Endometriosis
Rhabdomyosarcoma
Endometrial Cancer
Renal Fibrosis
Melanoma, Uveal
Pre-Eclampsia
Prostate Cancer
Lung Cancer
Gastric Cancer
Hepatocellular Carcinoma
Wilms Tumor 1