智鼠故事 
C57BL/6JCya-Ptpn11em1/Cya 基因敲除小鼠
基本信息
品系名称
C57BL/6JCya-Ptpn11em1/Cya
品系编号
KOCMP-19247-Ptpn11-B6J-VA
产品编号
S-KO-03899
基因名
Ptpn11
小鼠表型
基因别称
Syp，Shp2，PTP1D，PTP2C，SAP-2，SHP-2，SH-PTP2，SH-PTP3，2700084A17Rik
品系背景
C57BL/6JCya
修饰方式
全身性基因敲除
品系描述
Ptpn11位于小鼠的5号染色体，采用基因编辑技术，通过应用高通量电转受精卵方式，获得Ptpn11基因敲除小鼠，性成熟后取精子冻存。
相关疾病：
Noonan Syndrome 1
Juvenile Myelomonocytic Leukemia
Metachondromatosis
Leopard Syndrome 1
Noonan Syndrome with Multiple Lentigines
Rasopathy
Lymphoma
Ptosis
Tricuspid Valve Insufficiency
Noonan Syndrome 3
Patent Ductus Arteriosus 1
Patent Foramen Ovale
Noonan Syndrome-Like Disorder with or Without Juvenile Myelomonocytic Leukemia
Atrial Septal Defect 2
Epicanthus
Pseudo-Turner Syndrome
Noonan Syndrome and Noonan-Related Syndrome
Scoliosis
Strabismus
Specific Learning Disability
Hydrops Fetalis, Nonimmune
Hypertrophic Cardiomyopathy
Microcephaly
Rhabdomyosarcoma, Embryonal, 2
Myelodysplastic Syndrome
Acute Megakaryoblastic Leukemia in Down Syndrome
Miyoshi Muscular Dystrophy
Werner Syndrome
Brain Cancer
Gastric Adenocarcinoma
Leukemia, Acute Myeloid
Thrombocytopenia
Plasma Cell Neoplasm
Leukemia, Acute Lymphoblastic
Neuroblastoma
Lung Squamous Cell Carcinoma
Myeloma, Multiple
Autism Spectrum Disorder
Leukemia, Chronic Lymphocytic
Lung Cancer Susceptibility 3
Lung Cancer
质控标准
精子检测
① 冷冻前验证精子活力观察
② 冷冻验证每批次进行复苏验证
品系状态
活体
环境标准
SPF
供应地区
全球范围
