智鼠故事 
C57BL/6JCya-Ttnem1/Cya 基因敲除小鼠
基本信息
品系名称
C57BL/6JCya-Ttnem1/Cya
品系编号
KOCMP-22138-Ttn-B6J-VA
产品编号
S-KO-05587
基因名
Ttn
小鼠表型
基因别称
L56，mdm，shru，1100001C23Rik，2310036G12Rik，2310057K23Rik，2310074I15Rik，D330041I19Rik，D830007G01Rik
品系背景
C57BL/6JCya
修饰方式
全身性基因敲除
品系描述
Ttn位于小鼠的2号染色体，采用基因编辑技术，通过应用高通量电转受精卵方式，获得Ttn基因敲除小鼠，性成熟后取精子冻存。
相关疾病：
Myopathy, Myofibrillar, 9, with Early Respiratory Failure
Congenital Myopathy 5 with Cardiomyopathy
Cardiomyopathy, Dilated, 1g
Cardiomyopathy, Familial Hypertrophic, 9
Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 10
Tibial Muscular Dystrophy, Tardive
Tibial Muscular Dystrophy
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2j
Third-Degree Atrioventricular Block
Childhood-Onset Progressive Contractures-Limb-Girdle Weakness-Muscle Dystrophy Syndrome
Dilated Cardiomyopathy
Centronuclear Myopathy
Myopathy, Myofibrillar, 1
Myopathy, Myofibrillar, 4
Cardiomyopathy, Dilated, 1h
Arrhythmogenic Right Ventricular Dysplasia, Familial, 1
Myopathy
Neuromuscular Disease
Congenital Myopathy 1b, Autosomal Recessive
Orofacial Cleft 1
Left Ventricular Noncompaction
Congenital Myopathy 3 with Rigid Spine
Myopathy, Centronuclear, 2
Cardiomyopathy, Dilated, 1a
Sudden Infant Death Syndrome
Cardiomyopathy, Dilated, 1b
Hypertrophic Cardiomyopathy
Familial Isolated Dilated Cardiomyopathy
Congenital Myopathy
Myocarditis
Muscular Dystrophy
Limb-Girdle Muscular Dystrophy
Left Ventricular Noncompaction 2
Wolff-Parkinson-White Syndrome
Orthostatic Intolerance
Restrictive Cardiomyopathy
Cerebral Palsy
Cardiomyopathy, Dilated, 1e
Scoliosis
Familial Atrial Fibrillation
质控标准
精子检测
① 冷冻前验证精子活力观察
② 冷冻验证每批次进行复苏验证
品系状态
活体
环境标准
SPF
供应地区
全球范围
