智鼠故事 
hACE2-All CDS-B6J
新冠模型
* 使用本品系发表的文献需注明：hACE2-All CDS-B6J mice (Catalog C001191) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
本模型使用人的ACE2 CDS取代小鼠内源性的Ace2序列（保留了小鼠信号肽序列），实现由小鼠内源性Ace2调控元件指导hACE2的表达。基因位于X染色体上，纯合子雌性和半合子雄性是可存活且可育的。
相关疾病：
Covid-19
Hartnup Disorder
Influenza
Critical Covid-19
Long Covid
Coronavirus Infectious Disease
Non-Severe Covid-19
Severe Acute Respiratory Syndrome
Viral Pneumonia
Ebola Hemorrhagic Fever
Miller Fisher Syndrome
Severe Covid-19
Acute Hemorrhagic Conjunctivitis
Croup
Critical Illness Polyneuropathy
Avian Influenza
Inflammatory and Toxic Neuropathy
Extrinsic Cardiomyopathy
Conjunctival Disease
Acute Necrotizing Encephalitis
Nephrosclerosis
Meconium Aspiration Syndrome
Von Economo's Disease
Acute Pulmonary Heart Disease
Acute Cor Pulmonale
Pulmonary Embolism
Orchitis
Hypertension, Essential
Viral Exanthem
Pneumonia
Chagas Disease
Pulmonary Artery Disease
Myocarditis
Acute Myocarditis
Acute Disseminated Encephalomyelitis
Herpangina
Acute Interstitial Pneumonia
Acute Hemorrhagic Encephalitis
Bell's Palsy
Common Cold
Viral Infectious Disease
Subacute Thyroiditis
Kidney Disease
Mesenteric Lymphadenitis
Pericardium Disease
Congestive Heart Failure
Chickenpox
Postural Orthostatic Tachycardia Syndrome
Middle East Respiratory Syndrome
Febrile Seizures, Familial, 5
Acute Kidney Tubular Necrosis
Acute Conjunctivitis
Tracheitis
Acalculous Cholecystitis
Transverse Myelitis
Cardiovascular System Disease
West Nile Encephalitis
Bronchopneumonia
Viral Encephalitis
Malaria
Diabetes Mellitus, Ketosis-Prone
Geographic Tongue
Abducens Palsy
Mucormycosis
Myocardial Infarction
Lymph Node Disease
Postinflammatory Pulmonary Fibrosis
Acute Inferolateral Myocardial Infarction
Adult Respiratory Distress Syndrome
Parotid Disease
Bacterial Pneumonia
Pityriasis Rosea
Respiratory Failure
Marburg Hemorrhagic Fever
Viral Laryngitis
Cavernous Sinus Thrombosis
Atrophic Glossitis
Ischemic Colitis
Facial Paralysis
Facial Nerve Disease
Salivary Gland Disease
Blood Coagulation Disease
Postencephalitic Parkinson Disease
Pericardial Effusion
Autoimmune Disease of Peripheral Nervous System
Heart Aneurysm
Cranial Nerve Palsy
Coronary Aneurysm
Lipoprotein Quantitative Trait Locus
Androgenic Alopecia
Aspiration Pneumonia
Bacterial Sepsis
Poliomyelitis
Heart Disease
Nose Disease
Nasal Cavity Disease
Cecal Disease
Laryngitis
Testicular Disease
Epididymis Disease
Plague
Hemophagocytic Lymphohistiocytosis
Amebiasis
Pulmonary Hypertension
Yellow Fever
Bronchial Disease
Central Nervous System Origin Vertigo
Diabetes Mellitus
Leukocyte Disease
Mechanical Ectropion
Type 2 Diabetes Mellitus
Blood Platelet Disease
Parasitic Protozoa Infectious Disease
Retinitis Pigmentosa 40
Asthma
Stroke, Ischemic
Pulmonary Disease, Chronic Obstructive
Azoospermia
Heart Conduction Disease
Immune Deficiency Disease
Interstitial Lung Disease 2
Patent Foramen Ovale
Body Mass Index Quantitative Trait Locus 11
Peripheral Nervous System Disease
Nervous System Disease
Dilated Cardiomyopathy
应用领域
新冠相关研究
疫苗、抑制剂的药效及安全性评价
自身免疫性疾病研究
发表文献
Research square
2022.03
Signal Transduction and Targeted Therapy
2023.03
Small Methods
2022.05
nature microbiology
2022.08
EMBO Molecular Medicine
2022.03
* 使用本品系发表的文献需注明：hACE2-All CDS-B6J mice (Catalog C001191) were purchased from Cyagen.
