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hACE2-All CDS-B6J
产品名称：
hACE2-All CDS-B6J
产品编号：
C001191
品系背景：
C57BL/6JCya
文件下载：
C001191_hACE2-All CDS-B6J小鼠_vD.pdf
新冠模型
* 使用本品系发表的文献需注明：hACE2-All CDS-B6J mice (Catalog C001191) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
本模型使用人的ACE2 CDS取代小鼠内源性的Ace2序列（保留了小鼠信号肽序列），实现由小鼠内源性Ace2调控元件指导hACE2的表达。基因位于X染色体上，纯合子雌性和半合子雄性是可存活且可育的。
应用领域
新冠相关研究
疫苗、抑制剂的药效及安全性评价
自身免疫性疾病研究
发表文献
EMBO Molecular Medicine
2022.03
SARS-CoV-2 Spike Spurs Intestinal Inflammation via VEGF Production in Enterocytes
Small Methods
2022.05
A Class of Shark-Derived Single-Domain Antibodies can Broadly Neutralize SARS-Related Coronaviruses and the Structural Basis of Neutralization and Omicron Escape
Research square
2022.03
A population antibody response against SARS-CoV-2 with differential neutralization activities towards the Delta and Omicron variants
bioRxiv
2022.07
Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE2 in both cell and in vivo mouse models
nature microbiology
2022.08
SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope
Signal Transduction and Targeted Therapy
2023.03
SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy
* 使用本品系发表的文献需注明：hACE2-All CDS-B6J mice (Catalog C001191) were purchased from Cyagen.