智鼠故事 
C-NKG-hIL15
重度免疫缺陷鼠
* 使用本品系发表的文献需注明：C-NKG-hIL15 mice (Catalog C001513) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
C-NKG-hIL15小鼠是在C-NKG小鼠的背景上敲入人源IL15基因所构建的，与C-NKG小鼠相比，C-NKG-hIL15小鼠在HSC或PBMC移植后能显著提升人源NK细胞重建比例，可用于靶向NK细胞的免疫疗法开发和药物评价。
相关疾病：
Severe Combined Immunodeficiency, X-Linked
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma
Severe Combined Immunodeficiency
Celiac Disease 1
Tropical Spastic Paraparesis
Salmonellosis
Radiculopathy
Acquired Immunodeficiency Syndrome
Melioidosis
Mycosis Fungoides
Visceral Leishmaniasis
Combined Immunodeficiency
Rheumatoid Arthritis
Human Immunodeficiency Virus Infectious Disease
Lymphopenia
Extrinsic Allergic Alveolitis
Inflammatory Bowel Disease 30
Viral Infectious Disease
Aspergillosis
Sezary's Disease
Nk Cell Deficiency
Lung Disease
Immune Deficiency Disease
Capillary Leak Syndrome
Psoriasis
Common Variable Immunodeficiency
Type 1 Diabetes Mellitus
Malaria
Arthritis
Inflammatory Bowel Disease
Lymphocytic Gastritis
Pre-Eclampsia
Colorectal Cancer
Pfeiffer Syndrome
Systemic Lupus Erythematosus
Sarcoidosis 1
Autoimmune Disease
Rhabdomyosarcoma
T-Cell Large Granular Lymphocyte Leukemia
Multiple Sclerosis
Immunodeficiency 41 with Lymphoproliferation and Autoimmunity
Bacterial Infectious Disease
Autoimmune Disease of Gastrointestinal Tract
Adult T-Cell Leukemia/lymphoma
Lymphoma, Non-Hodgkin, Familial
Cerebral Palsy
Leukocyte Disease
Lung Cancer
Gastric Body Carcinoma
Hepatocellular Carcinoma
Primary Bacterial Infectious Disease
Asthma
Myeloma, Multiple
Renal Cell Carcinoma, Nonpapillary
Ceftazidime Allergy
Diabetes Mellitus
Body Mass Index Quantitative Trait Locus 11
Behcet Syndrome
Skin Disease
Leukemia, Acute Lymphoblastic
Connective Tissue Disease
Leukemia, Acute Myeloid
Leukemia, Chronic Lymphocytic
Peripheral Nervous System Disease
Nervous System Disease
应用领域
免疫系统人源化小鼠模型构建
人类免疫系统、造血系统研究
人源细胞系异种移植（CDX）及药物筛选和药效评价
患者肿瘤组织异种移植（PDX）及药物筛选和药效评价
NK细胞发育机制研究、NK细胞相关的肿瘤免疫疗法开发、抗体依赖性的NK细胞介导的毒性（ADCC）研究
