智鼠故事 
B6-hGDF15
靶点人源化模型
* 使用本品系发表的文献需注明：B6-hGDF15 mice (Catalog C001520) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
本品系是通过基因编辑技术将小鼠Gdf15基因中编码内源结构域的序列替换为人GDF15基因中编码结构域的序列，获得表达人源GDF15蛋白的模型。B6-hGDF15小鼠可用于代谢疾病、心血管疾病和肿瘤发生发展等研究，助力GDF15靶向药物的研发、筛选和临床前药理药效评估。
相关疾病：
Heart Disease
Colorectal Cancer
Beta-Thalassemia
Thalassemia
Pancreatic Adenocarcinoma
Pulmonary Embolism
Alpha-Thalassemia
Prostate Cancer
Polycythemia Vera
Tetralogy of Fallot
Lung Cancer
Beta-Thalassemia Intermedia
Beta-Thalassemia Major
Pancreatic Cancer
Gastric Cancer
Myocardial Infarction
Soft Palate Cancer
Hepatocellular Carcinoma
Deficiency Anemia
Diabetes Mellitus
Hemoglobin H Disease
Ovarian Cancer
Mitochondrial Myopathy
Heart Conduction Disease
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes
Hypertension, Essential
Dilated Cardiomyopathy
应用领域
心脏病等心血管疾病研究
糖尿病、厌食症等代谢疾病研究
结直肠癌、前列腺癌等癌症发生发展研究
GDF15靶向药物的研发、筛选和临床前评估
