智鼠故事 
Col1a2-iCre
复苏/繁育服务
Cre工具鼠
* 使用本品系发表的文献需注明：Col1a2-iCre mice (Catalog C001528) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
Col1a2-iCre小鼠是通过基因编辑技术将密码子优化后的Cre重组酶（iCre）基因表达元件整合到小鼠内源性Col1a2基因的终止密码子处所构建的。该构建策略使Cre重组酶表达模式与内源性基因保持一致，同时保留小鼠Col1a2基因的正常表达。当Col1a2-iCre小鼠与含有loxP位点的小鼠杂交后，子代小鼠可在成纤维细胞中引发由Cre重组酶介导的loxP位点间的序列重组。
相关疾病：
Osteogenesis Imperfecta, Type Iii
Osteogenesis Imperfecta, Type Iv
Ehlers-Danlos Syndrome, Cardiac Valvular Type
Combined Osteogenesis Imperfecta and Ehlers-Danlos Syndrome 2
Osteogenesis Imperfecta, Type Ii
Ehlers-Danlos Syndrome, Arthrochalasia Type, 2
Osteoporosis
Osteogenesis Imperfecta, Type I
Brittle Bone Disorder
Primary Bone Dysplasia
Dentinogenesis Imperfecta
Ehlers-Danlos Syndrome, Classic Type, 1
Osteochondrodysplasia
Ehlers-Danlos Syndrome
Ehlers-Danlos/osteogenesis Imperfecta Syndrome
High Bone Mass Osteogenesis Imperfecta
Classic Ehlers-Danlos Syndrome
Ehlers-Danlos Syndrome, Arthrochalasia Type, 1
Orthostatic Hypotension
Bruck Syndrome 1
