Col7a1 KO小鼠_其他模型小鼠_构建

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Col7a1 KO

产品名称：

Col7a1 KO

产品编号：

C001539

品系背景：

C57BL/6JCya

方案下载：

C001539_Col7a1 KO小鼠_vA.pdf

其他模型

* 使用本品系发表的文献需注明：Col7a1 KO mice (Catalog C001539) were purchased from Cyagen.

了解更多Col7a1基因研究文献

交付类型

周龄

性别

基因型

数量

只

品系描述

Col7a1 KO小鼠是利用基因编辑技术敲除人类COL7A1基因在小鼠体内的同源基因Col7a1所构建的营养不良性大疱性表皮松解症（DEB）研究模型，纯合Col7a1 KO小鼠缺少Col7a1基因和COL7A1蛋白的表达，在出生后第一天就出现前后脚掌皮肤的红肿和起泡症状，并在出生后3天内死亡。组织学检测结果显示，Col7a1 KO小鼠皮肤出现显著的皮下水肿，并存在表皮和真皮层分离现象，这与临床上人类营养不良性大疱性表皮松解症（DEB）致病机制和病理特征大致相同。因此，Col7a1 KO小鼠可用于营养不良性大疱性表皮松解症（DEB）的机制研究，以及治疗药物的研发、筛选和评价。

相关疾病：

Epidermolysis Bullosa Pruriginosa

Transient Bullous Dermolysis of the Newborn

Epidermolysis Bullosa Dystrophica, Autosomal Recessive

Nail Disorder, Nonsyndromic Congenital, 8

Epidermolysis Bullosa Dystrophica, Pretibial

Epidermolysis Bullosa Dystrophica, Autosomal Dominant

Epidermolysis Bullosa with Congenital Localized Absence of Skin and Deformity of Nails

Autosomal Dominant Generalized Dystrophic Epidermolysis Bullosa

Epidermolysis Bullosa Dystrophica

Recessive Dystrophic Epidermolysis Bullosa

Hyperpigmentation of the Skin

Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form

Localized Dystrophic Epidermolysis Bullosa, Pretibial Form

Localized Dystrophic Epidermolysis Bullosa, Nails Only

Localized Dystrophic Epidermolysis Bullosa, Acral Form

Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form

Skin Disease

Nail Disorder, Nonsyndromic Congenital, 4

Beckwith-Wiedemann Syndrome

Microcephaly

Thyroid Gland Disease

Epidermolytic Hyperkeratosis

Epidermolytic Hyperkeratosis 1

Ichthyosis

Nevus, Epidermal

Hepatoblastoma

应用领域

大疱性表皮松解症（EB）