智鼠故事 
B6-hBAFF(TNFSF13B)
复苏/繁育服务
靶点人源化模型
* 使用本品系发表的文献需注明：B6-hBAFF(TNFSF13B) mice (Catalog C001621) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
B6-hBAFF(TNFSF13B)小鼠是利用基因编辑技术将编码人源 TNFSF13B 蛋白胞外域的蛋白编码序列（CDS）整合到小鼠 Tnfsf13b 基因特定位点中构建的人源化模型，同时保留了编码小鼠蛋白胞质和跨膜结构域（aa.1-68）的内源性基因序列。纯合 B6-hBAFF(TNFSF13B)小鼠可存活且可育，可用于自身免疫性疾病和特定 B 细胞恶性肿瘤的病理机制及治疗手段研究，以及 BAFF 靶向药物的筛选、研发及临床前药效和安全性评价。
相关疾病：
Autoimmune Disease
Cryoglobulinemia
Common Variable Immunodeficiency
Ascaris Lumbricoides Infection
Neuromyelitis Optica
Vasculitis
Macroglobulinemia
Myasthenia Gravis
Autoimmune Disease of Exocrine System
Sjogren Syndrome
Pemphigus Foliaceus
Primary Sjögren Syndrome
Bullous Pemphigoid
Systemic Lupus Erythematosus
Purpura
Refractory Plasma Cell Neoplasm
Pemphigus Vulgaris, Familial
B-Cell Lymphoma
Burkitt Lymphoma
Potocki-Shaffer Syndrome
Pemphigus
Rheumatoid Arthritis
Multiple Sclerosis
Bronchiolitis Obliterans
Connective Tissue Disease
Immunodeficiency with Hyper-Igm, Type 4
Hyperglobulinemic Purpura
Lymphoid Interstitial Pneumonia
B Cell Deficiency
Xerophthalmia
Temporal Arteritis
Autoimmune Disease of Blood
Lymphoma, Non-Hodgkin, Familial
Immune-Complex Glomerulonephritis
Igg4-Related Disease
Polyclonal Hypergammaglobulinemia
Immunoglobulin Alpha Deficiency
Follicular Lymphoma
Sialadenitis
Lymphoproliferative Syndrome
Dacryoadenitis
Immunodeficiency with Hyper-Igm, Type 2
Mikulicz Disease
Primary Thrombocytopenia
Cutaneous Lupus Erythematosus
Keratoconjunctivitis Sicca
Proliferative Glomerulonephritis
Leukemia, Chronic Lymphocytic
Heart Block, Congenital
Autoimmune Disease of Musculoskeletal System
Immunodeficiency with Hyper-Igm, Type 1
Malaria
Progressive Multifocal Leukoencephalopathy
Chromosomal Deletion Syndrome
Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
Thrombocytopenia
Anemia, Autoimmune Hemolytic
Granulomatosis with Polyangiitis
Autoimmune Disease of Peripheral Nervous System
Marginal Zone Lymphoma
Salivary Gland Disease
Asthma
Monoclonal Gammopathy of Uncertain Significance
Lacrimal Apparatus Disease
Immune Deficiency Disease
Lymphoma, Hodgkin, Classic
Plasma Protein Metabolism Disease
Hypersensitivity Reaction Type Iv Disease
Myeloma, Multiple
Asymmetric Motor Neuropathy
Optic Nerve Disease
Mantle Cell Lymphoma
Behcet Syndrome
应用领域
TNFSF13B 靶向药物的筛选、开发和临床前药效评价
自身免疫性疾病和特定 B 细胞恶性肿瘤的病理机制及治疗手段研究
