智鼠故事 
B6-hCD38
复苏/繁育服务
靶点人源化模型
* 使用本品系发表的文献需注明：B6-hCD38 mice (Catalog C001638) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
B6-hCD38 小鼠是通过基因编辑技术将小鼠 Cd38 基因的部分 2 号外显子（起始于 p.87Q）替换为人类 CD38 基因中的部分胞外域及小鼠 Cd38 基因的 3'UTR 所构建的人源化模型。该模型可用于血液系统恶性肿瘤和自身免疫性疾病的病理机制与治疗方法研究，以及 CD38 靶向药物的筛选、研发以及临床前药效和安全性评估。
相关疾病：
Prolymphocytic Leukemia
Leukemia, Chronic Lymphocytic 2
Extramedullary Plasmacytoma
Pellagra
Lymphoma
Human Immunodeficiency Virus Infectious Disease
Solitary Osseous Plasmacytoma
Acquired Immunodeficiency Syndrome
Smoldering Myeloma
Immunoglobulin Light Chain Amyloidosis
Leukemia
Monoclonal Gammopathy of Uncertain Significance
Blood Protein Disease
Houge-Janssens Syndrome 2
Richter's Syndrome
Invasive Malignant Thymoma
Lymphoproliferative Syndrome
Non-Secretory Myeloma
Leukemia, Chronic Lymphocytic
Multicentric Castleman Disease
Refractory Plasma Cell Neoplasm
Bone Marrow Cancer
Leukocyte Disease
Gamma Heavy Chain Disease
Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma
Plasmablastic Lymphoma
Igg4-Related Disease
Spondylocostal Dysostosis 2, Autosomal Recessive
Intellectual Developmental Disorder, Autosomal Dominant 10
Neuroblastoma
Lymphoma, Non-Hodgkin, Familial
Mature B-Cell Neoplasm
Plasma Cell Leukemia
Chromosome 13q14 Deletion Syndrome
B-Cell Expansion with Nfkb and T-Cell Anergy
Refractory Hematologic Cancer
Immune Deficiency Disease
Myeloma, Multiple
Systemic Lupus Erythematosus
Mechanical Ectropion
Evans' Syndrome
B Cell Deficiency
Leukemia, Acute Lymphoblastic
Plasma Protein Metabolism Disease
Marginal Zone Lymphoma
Burkitt Lymphoma
Keratopathy
Anemia, Autoimmune Hemolytic
Castleman Disease
Mantle Cell Lymphoma
Blood Platelet Disease
Plasma Cell Neoplasm
Asthma
Blood Coagulation Disease
Diffuse Large B-Cell Lymphoma
Submucous Uterine Fibroid
Common Variable Immunodeficiency
Autism
Potocki-Shaffer Syndrome
Pancytopenia
Leukemia, Acute Myeloid
Diabetes Mellitus
Severe Combined Immunodeficiency
Leukemia, Chronic Myeloid
Myelodysplastic Syndrome
Deficiency Anemia
Acute Promyelocytic Leukemia
Nervous System Disease
应用领域
CD38 靶向药物筛选、开发和临床前药效评价
血液系统恶性肿瘤的病理机制及治疗手段研究
自身免疫性疾病的病理机制及治疗手段研究
