智鼠故事 
Rosa26-hHRAS
自发肿瘤模型
* 使用本品系发表的文献需注明：Rosa26-hHRAS mice (Catalog I001213) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
Rosa26-hHRAS 小鼠通过基因编辑技术将携带 c.450+180A>G 突变的人源 HRAS 基因整合到小鼠 Rosa26安全位点中所构建的人源化模型，c.450+180A>G 突变的引入可明显增强 HRAS 基因的表达。该模型可用于基因毒性化合物及非基因毒性化合物致癌性的快速体内测试，研究 HRAS 癌基因点突变对肿瘤发生发展的影响，以及开发和评估肿瘤预防或抑制疗法等。
相关疾病：
Costello Syndrome
Schimmelpenning-Feuerstein-Mims Syndrome
Thyroid Cancer, Nonmedullary, 2
Woolly Hair Nevus
Melanocytic Nevus Syndrome, Congenital
Bladder Cancer
Nevus, Epidermal
Large Congenital Melanocytic Nevus
Phakomatosis Pigmentokeratotica
Thyroid Cancer
Spermatocytoma
Noonan Syndrome and Noonan-Related Syndrome
Arteriovenous Malformation
Testicular Germ Cell Tumor
Lip and Oral Cavity Cancer
Hydrops Fetalis, Nonimmune
Rhabdomyosarcoma
Differentiated Thyroid Carcinoma
Rasopathy
Pseudo-Turner Syndrome
Noonan Syndrome 1
Cutaneous-Skeletal Hypophosphatemia Syndrome
Thymoma
Skin Squamous Cell Carcinoma
Adenoid Cystic Carcinoma
Noonan Syndrome 3
Ovarian Serous Cystadenocarcinoma
Pancreatic Adenocarcinoma
Uterine Carcinosarcoma
Skin Melanoma
Suppression of Tumorigenicity 12
Lung Squamous Cell Carcinoma
Melanoma
Myelodysplastic Syndrome
Plasma Cell Neoplasm
Renal Cell Carcinoma, Papillary, 1
Giant Cell Glioblastoma
Bladder Urothelial Carcinoma
Gliosarcoma
Gastric Adenocarcinoma
Lung Cancer
Myeloma, Multiple
Glioblastoma
Lung Cancer Susceptibility 3
Esophageal Cancer
Squamous Cell Carcinoma, Head and Neck
Cervical Cancer
Leukemia, Chronic Lymphocytic
Leukemia, Acute Myeloid
Hepatocellular Carcinoma
应用领域
基因毒性化合物及非基因毒性化合物致癌性的快速体内测试
HRAS 癌基因点突变对肿瘤发生发展的影响
