智鼠故事 
BALB/c;B6J-Rosa26-HRAS
产品名称：
BALB/c;B6J-Rosa26-HRAS
产品编号：
I001214
品系背景：
BALB/c;B6JCya
* 使用本品系发表的文献需注明：BALB/c;B6J-Rosa26-HRAS mice (Catalog I001214) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
品系描述
BALB/c;B6J-Rosa26-HRAS 小鼠是通过将 C57BL/6JCya 背景的 Rosa26-hHRAS 小鼠（产品编号：I001213）与 BALB/cAnCya 小鼠交配获得的。这一杂交品系对基因毒性和非基因毒性的人类致癌物质具有更高的敏感性。BALB/c;B6J-Rosa26-HRAS 小鼠可用于基因毒性化合物及非基因毒性化合物致癌性的快速体内测试，研究HRAS 癌基因点突变对肿瘤发生发展的影响，以及评估和设计肿瘤预防或抑制疗法等。
相关疾病：
Costello Syndrome
Schimmelpenning-Feuerstein-Mims Syndrome
Thyroid Cancer, Nonmedullary, 2
Woolly Hair Nevus
Melanocytic Nevus Syndrome, Congenital
Bladder Cancer
Nevus, Epidermal
Large Congenital Melanocytic Nevus
Phakomatosis Pigmentokeratotica
Thyroid Cancer
Spermatocytoma
Noonan Syndrome and Noonan-Related Syndrome
Arteriovenous Malformation
Testicular Germ Cell Tumor
Lip and Oral Cavity Cancer
Hydrops Fetalis, Nonimmune
Rhabdomyosarcoma
Differentiated Thyroid Carcinoma
Rasopathy
Pseudo-Turner Syndrome
Noonan Syndrome 1
Cutaneous-Skeletal Hypophosphatemia Syndrome
Thymoma
Skin Squamous Cell Carcinoma
Adenoid Cystic Carcinoma
Noonan Syndrome 3
Ovarian Serous Cystadenocarcinoma
Pancreatic Adenocarcinoma
Uterine Carcinosarcoma
Skin Melanoma
Suppression of Tumorigenicity 12
Lung Squamous Cell Carcinoma
Melanoma
Myelodysplastic Syndrome
Plasma Cell Neoplasm
Renal Cell Carcinoma, Papillary, 1
Giant Cell Glioblastoma
Bladder Urothelial Carcinoma
Gliosarcoma
Gastric Adenocarcinoma
Lung Cancer
Myeloma, Multiple
Glioblastoma
Lung Cancer Susceptibility 3
Esophageal Cancer
Squamous Cell Carcinoma, Head and Neck
Cervical Cancer
Leukemia, Chronic Lymphocytic
Leukemia, Acute Myeloid
Hepatocellular Carcinoma
应用领域
基因毒性化合物及非基因毒性化合物致癌性的快速体内测试
HRAS 癌基因点突变对肿瘤发生发展影响研究
